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Benzodiazepines Modulate GABA(A) Receptors by Regulating the Preactivation Step after GABA Binding
GABA(A) receptors (GABA(A)Rs) composed of αβγ subunits are allosterically modulated by the benzodiazepines (BDZs). Agonists at the BDZ binding site potentiate submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA. Although BDZs were initially thought to affect the bindi...
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| Udgivet i: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6703631/ https://ncbi.nlm.nih.gov/pubmed/22539833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5663-11.2012 |
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