Gα(olf) Mutation Allows Parsing the Role of cAMP-Dependent and Extracellular Signal-Regulated Kinase-Dependent Signaling in l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia

Although l-3,4-dihydroxyphenylalanine (l-DOPA) remains the reference treatment of Parkinson's disease, its long-term beneficial effects are hindered by l-DOPA-induced dyskinesia (LID). In the dopamine (DA)-denervated striatum, l-DOPA activates DA D(1) receptor (D(1)R) signaling, including cAMP-...

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Published in:J Neurosci
Main Authors: Alcacer, Cristina, Santini, Emanuela, Valjent, Emmanuel, Gaven, Florence, Girault, Jean-Antoine, Hervé, Denis
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703620/
https://ncbi.nlm.nih.gov/pubmed/22539851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0837-12.2012
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