Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in l-DOPA-Induced Dyskinesia

The molecular basis of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's disease, is still unclear. We show that attenuation of cAMP signaling in the medium spiny neurons of the striatum, achieved by genetic inacti...

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Pubblicato in:J Neurosci
Autori principali: Santini, Emanuela, Valjent, Emmanuel, Usiello, Alessandro, Carta, Manolo, Borgkvist, Anders, Girault, Jean-Antoine, Hervé, Denis, Greengard, Paul, Fisone, Gilberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672217/
https://ncbi.nlm.nih.gov/pubmed/17596448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0852-07.2007
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