Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism

Dyskinesia, a motor complication caused by prolonged administration of the antiparkinsonian drug l-3,4-dihydroxyphenylalanine (l-DOPA), is accompanied by activation of cAMP signaling and hyperphosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). Here, we show that...

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Main Authors: Santini, Emanuela, Feyder, Michael, Gangarossa, Giuseppe, Bateup, Helen S., Greengard, Paul, Fisone, Gilberto
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Neurobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431653/
https://ncbi.nlm.nih.gov/pubmed/22753408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.388413
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