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Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2
Nuclear receptor-binding SET domain protein 2 (NSD2) is a histone H3 lysine 36 (H3K36)-specific methyltransferase enzyme that is overexpressed in a number of cancers, including multiple myeloma. NSD2 binds to S-adenosyl-L-methionine (SAM) and nucleosome substrates to catalyze the transfer of a methy...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6702673/ https://ncbi.nlm.nih.gov/pubmed/27183271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b01612 |
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