The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

Overexpression of anti-apoptotic proteins MCL1 and Bcl-xL are frequently observed in many cancers. Inhibitors targeting MCL1 are in clinical development, however numerous cancer models are intrinsically resistant to this approach. To discover mechanisms underlying resistance to MCL1 inhibition, we p...

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Publicat a:eLife
Autors principals: Kabir, Shaheen, Cidado, Justin, Andersen, Courtney, Dick, Cortni, Lin, Pei-Chun, Mitros, Therese, Ma, Hong, Baik, Seung Hyun, Belmonte, Matthew A, Drew, Lisa, Corn, Jacob E
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701926/
https://ncbi.nlm.nih.gov/pubmed/31294695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44288
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