Dysregulated glial differentiation in schizophrenia may be relieved by suppression of SMAD4 and REST-dependent signaling

Astrocytic differentiation is developmentally impaired in patients with childhood-onset schizophrenia (SCZ). To determine why, we used genetic gain- and loss-of-function studies to establish the contributions of differentially-expressed transcriptional regulators to the defective differentiation of...

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Publicat a:Cell Rep
Autors principals: Liu, Zhengshan, Osipovitch, Mikhail, Benraiss, Abdellatif, Huynh, Nguyen P. T., Foti, Rossana, Bates, Janna, Chandler-Militello, Devin, Findling, Robert, Tesar, Paul J., Nedergaard, Maiken, Windrem, Martha S., Goldman, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700735/
https://ncbi.nlm.nih.gov/pubmed/31242417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.088
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