Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase

[Image: see text] De novo macrocyclic peptides, derived using selection technologies such as phage and mRNA display, present unique and unexpected solutions to challenging biological problems. This is due in part to their unusual folds, which are able to present side chains in ways not available to...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Goldbach, Leander, Vermeulen, Bram J. A., Caner, Sami, Liu, Minglong, Tysoe, Christina, van Gijzel, Lieke, Yoshisada, Ryoji, Trellet, Mikael, van Ingen, Hugo, Brayer, Gary D., Bonvin, Alexandre M. J. J., Jongkees, Seino A. K.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700688/
https://ncbi.nlm.nih.gov/pubmed/31241898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00290
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