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Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation

Genetic code reprogramming is a powerful approach to controlled protein modification. A remaining challenge, however, is the generation of vacant codons. We targeted the initiation machinery of E. coli, showing that restriction of the formyl donor or inhibition of the formyl transferase during in vi...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Liu, Minglong, Thijssen, Vito, Jongkees, Seino A. K.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756408/
https://ncbi.nlm.nih.gov/pubmed/32840944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202003779
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