p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation

Recent studies show p85α up-regulates epidermal growth factor (EGF) receptor, thereby promoting malignant cell transformation and migration in normal mouse embryonic fibroblasts (MEFs). However, the potential role of p85α in human bladder cancer (BC) remains unknown. Here, we show that p85α is down-...

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Vydáno v:Neoplasia
Hlavní autoři: Wang, Jingjing, Zhang, Ning, Peng, Minggang, Hua, Xiaohui, Huang, Chao, Tian, Zhongxian, Xie, Qipeng, Zhu, Junlan, Li, Jingxia, Huang, Haishan, Huang, Chuanshu
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2019
Témata:
Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700442/
https://ncbi.nlm.nih.gov/pubmed/31401412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2019.07.007
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