Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer

Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo synthesis of purines, and certain amino acids...

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Bibliographic Details
Published in:Transl Oncol
Main Authors: Eich, Marie-Lisa, Rodriguez Pena, Maria Del Carmen, Chandrashekar, Darshan Shimoga, Chaux, Alcides, Agarwal, Sumit, Gordetsky, Jennifer B., Ferguson, James E., Sonpavde, Guru P., Netto, George J., Varambally, Sooryanarayana
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2019
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Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700437/
https://ncbi.nlm.nih.gov/pubmed/31401334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.07.012
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