Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency

Folate-mediated one-carbon metabolism is a metabolic network of interconnected pathways that is required for the de novo synthesis of three of the four DNA bases and the remethylation of homocysteine to methionine. Previous studies have indicated that the thymidylate synthesis and homocysteine remet...

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Bibliografiske detaljer
Main Authors: Field, Martha S., Kamynina, Elena, Agunloye, Olufunmilayo C., Liebenthal, Rebecca P., Lamarre, Simon G., Brosnan, Margaret E., Brosnan, John T., Stover, Patrick J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207979/
https://ncbi.nlm.nih.gov/pubmed/25213861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599589
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