Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency

Folate-mediated one-carbon metabolism is a metabolic network of interconnected pathways that is required for the de novo synthesis of three of the four DNA bases and the remethylation of homocysteine to methionine. Previous studies have indicated that the thymidylate synthesis and homocysteine remet...

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Main Authors: Field, Martha S., Kamynina, Elena, Agunloye, Olufunmilayo C., Liebenthal, Rebecca P., Lamarre, Simon G., Brosnan, Margaret E., Brosnan, John T., Stover, Patrick J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Metabolism
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207979/
https://ncbi.nlm.nih.gov/pubmed/25213861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599589
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