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Folate rescues vitamin B(12) depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
Clinical vitamin B(12) deficiency can result in megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis. In the cytosol, vitamin B(...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5441772/ https://ncbi.nlm.nih.gov/pubmed/28461497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619582114 |
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