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Folate rescues vitamin B(12) depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability

Clinical vitamin B(12) deficiency can result in megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis. In the cytosol, vitamin B(...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Palmer, Ashley M., Kamynina, Elena, Field, Martha S., Stover, Patrick J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441772/
https://ncbi.nlm.nih.gov/pubmed/28461497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619582114
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