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Folate rescues vitamin B(12) depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
Clinical vitamin B(12) deficiency can result in megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis. In the cytosol, vitamin B(...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5441772/ https://ncbi.nlm.nih.gov/pubmed/28461497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619582114 |
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