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Targeting Nuclear Thymidylate Biosynthesis
Thymidylate (dTMP) biosynthesis plays an essential and exclusive function in DNA synthesis and proper cell division, and therefore has been an attractive therapeutic target. Folate analogues, known as antifolates, and nucleotide analogs that inhibit the enzymatic action of the de novo thymidylate bi...
Gardado en:
| Publicado en: | Mol Aspects Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5253096/ https://ncbi.nlm.nih.gov/pubmed/27876557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mam.2016.11.005 |
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