Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses

T follicular helper (T(fh)) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult T(fh) cells at the transcriptomic level and demons...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mastelic-Gavillet, Beatris, Vono, Maria, Gonzalez-Dias, Patrícia, Ferreira, Frederico Moraes, Cardozo, Lucas, Lambert, Paul-Henri, Nakaya, Helder I., Siegrist, Claire-Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700230/
https://ncbi.nlm.nih.gov/pubmed/31456798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01845
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