A TLR7/8 Agonist-Including DOEPC-Based Cationic Liposome Formulation Mediates Its Adjuvanticity Through the Sustained Recruitment of Highly Activated Monocytes in a Type I IFN-Independent but NF-κB-Dependent Manner

Novel adjuvants, such as Toll-like receptors (TLRs) agonists, are needed for the development of new formulations able to circumvent limitations of current vaccines. Among TLRs, TLR7/8 agonists represent promising candidates, as they are well described to enhance antigen-specific antibody responses a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Auderset, Floriane, Belnoue, Elodie, Mastelic-Gavillet, Beatris, Lambert, Paul-Henri, Siegrist, Claire-Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686571/
https://ncbi.nlm.nih.gov/pubmed/33262759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.580974
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