Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the probability of emergence in the future. Currently...

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Vydáno v:Antiviral Res
Hlavní autoři: Brown, Ariane J., Won, John J., Graham, Rachel L., Dinnon, Kenneth H., Sims, Amy C., Feng, Joy Y., Cihlar, Tomas, Denison, Mark R., Baric, Ralph S., Sheahan, Timothy P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier B.V. 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699884/
https://ncbi.nlm.nih.gov/pubmed/31233808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2019.104541
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