Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the probability of emergence in the future. Currently...

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Udgivet i:Antiviral Res
Main Authors: Brown, Ariane J., Won, John J., Graham, Rachel L., Dinnon, Kenneth H., Sims, Amy C., Feng, Joy Y., Cihlar, Tomas, Denison, Mark R., Baric, Ralph S., Sheahan, Timothy P.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier B.V. 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699884/
https://ncbi.nlm.nih.gov/pubmed/31233808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2019.104541
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