Fluid Shear Stress Increases Osteocyte and Inhibits Osteoclasts via Downregulating Receptor-Activator of Nuclear Factor κB (RANK)/Osteoprotegerin Expression in Myeloma Microenvironment

BACKGROUND: The aim of this study was to determine the effects of myeloma cells exposed to fluid shear stress on osteocytes and osteoclasts, and clarify the potential underlying mechanisms. MATERIAL/METHODS: A flow and a non-flow model were established using a flow fluid chamber. The myeloma cell li...

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Sparad:
Bibliografiska uppgifter
I publikationen:Med Sci Monit
Huvudupphovsmän: Wang, Xiaotao, He, Yuchan, Tian, Shen, Zhu, Fangxiao, Huang, Bo, Zhang, Junyan, Chen, Zhong, Wang, Hangfei
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Scientific Literature, Inc. 2019
Ämnen:
Lab/In Vitro Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699202/
https://ncbi.nlm.nih.gov/pubmed/31400110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915986
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