Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways

Non-small-cell lung cancer (NSCLC) is the third most common cancer that spreads to the bone, resulting in osteolytic lesions caused by hyperactivation of osteoclasts. Activating mutations in epidermal growth factor receptor-tyrosine kinase (EGF-TK) are frequently associated with NSCLC, and afatinib...

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Detalhes bibliográficos
Publicado no:BMB Rep
Main Authors: Ihn, Hye Jung, Kim, Ju Ang, Bae, Yong Chul, Shin, Hong-In, Baek, Moon-Chang, Park, Eui Kyun
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422028/
https://ncbi.nlm.nih.gov/pubmed/28256196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2017.50.3.223
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