Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway

Abnormally elevated formation and activation of osteoclasts are primary causes for a majority of skeletal diseases. In this study, we found that KP-A159, a newly synthesized thiazolopyridine derivative, inhibited osteoclast differentiation and function in vitro, and inflammatory bone loss in vivo. K...

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Publicat a:PLoS One
Autors principals: Ihn, Hye Jung, Lee, Doohyun, Lee, Taeho, Kim, Sang-Hyun, Shin, Hong-In, Bae, Yong Chul, Hong, Jung Min, Park, Eui Kyun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633183/
https://ncbi.nlm.nih.gov/pubmed/26536233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142201
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