Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)–Mixed Lineage Kinase Domain-Like Protein (MLKL)–Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers

Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the pathogenesis of fatty liver diseases. Necroptosis is regulated by three key proteins: receptor-interacting serine...

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Vydáno v:Am J Pathol
Hlavní autoři: Ni, Hong-Min, Chao, Xiaojuan, Kaseff, Joshua, Deng, Fengyan, Wang, Shaogui, Shi, Ying-Hong, Li, Tiangang, Ding, Wen-Xing, Jaeschke, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698941/
https://ncbi.nlm.nih.gov/pubmed/31026418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.03.010
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