A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly-characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here,...

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Publicat a:Nat Cell Biol
Autors principals: Michel, Brittany C., D’Avino, Andrew R., Cassel, Seth H., Mashtalir, Nazar, McKenzie, Zachary M., McBride, Matthew J., Valencia, Alfredo M., Zhou, Qianhe, Bocker, Michael, Soares, Luis M.M., Pan, Joshua, Remillard, David I., Lareau, Caleb A., Zullow, Hayley J., Fortoul, Nora, Gray, Nathanael S., Bradner, James E., Chan, Ho Man, Kadoch, Cigall
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698386/
https://ncbi.nlm.nih.gov/pubmed/30397315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0221-1
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