A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly-characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here,...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Cell Biol
मुख्य लेखकों: Michel, Brittany C., D’Avino, Andrew R., Cassel, Seth H., Mashtalir, Nazar, McKenzie, Zachary M., McBride, Matthew J., Valencia, Alfredo M., Zhou, Qianhe, Bocker, Michael, Soares, Luis M.M., Pan, Joshua, Remillard, David I., Lareau, Caleb A., Zullow, Hayley J., Fortoul, Nora, Gray, Nathanael S., Bradner, James E., Chan, Ho Man, Kadoch, Cigall
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698386/
https://ncbi.nlm.nih.gov/pubmed/30397315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0221-1
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