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A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation
Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly-characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here,...
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| Publicat a: | Nat Cell Biol |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698386/ https://ncbi.nlm.nih.gov/pubmed/30397315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0221-1 |
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