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The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting

Perturbations to mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complexes have been widely implicated as driving events in cancer(1). One such perturbation is the dual loss of the SMARCA4 and SMARCA2 ATPase subunits in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)(2–5), SMARCA4-d...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Pan, Joshua, McKenzie, Zachary M., D’Avino, Andrew R., Mashtalir, Nazar, Lareau, Caleb A., St. Pierre, Roodolph, Wang, Lu, Shilatifard, Ali, Kadoch, Cigall
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755913/
https://ncbi.nlm.nih.gov/pubmed/30858614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0363-5
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