Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation

Insulin and insulin-like growth factor (IGF)-1 signaling in the thyroid are thought to be permissive for the coordinated regulation by thyroid-stimulating hormone (TSH) of thyrocyte proliferation and hormone production. However, the integrated role of insulin receptor (IR) and IGF-1 receptor (IGF-1R...

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Vydáno v:Int J Cancer
Hlavní autoři: Ock, Sangmi, Ahn, Jihyun, Lee, Seok Hong, Kim, Hyun Min, Kang, Hyun, Kim, Young-Kook, Kook, Hyun, Park, Woo Jin, Kim, Shin, Kimura, Shioko, Jung, Chan Kwon, Shong, Minho, Holzenberger, Martin, Abel, E. Dale, Lee, Tae Jin, Cho, Bo Youn, Kim, Ho-Shik, Kim, Jaetaek
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698377/
https://ncbi.nlm.nih.gov/pubmed/30070361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31779
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