Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts

While deletion of Akt1 results in a smaller heart size and Akt2(−/−) mice are mildly insulin resistant, Akt1(−/−)/Akt2(−/−) mice exhibit perinatal lethality, indicating a large degree of functional overlap between the isoforms of the serine/threonine kinase Akt. The present study aimed to determine...

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Publicado en:Biochim Biophys Acta Mol Basis Dis
Autores principales: Ock, Sangmi, Lee, Wang Soo, Kim, Hyun Min, Park, Kyu-Sang, Kim, Young-Kook, Kook, Hyun, Park, Woo Jin, Lee, Tae Jin, Abel, E. Dale, Kim, Jaetaek
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342503/
https://ncbi.nlm.nih.gov/pubmed/29378301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.01.022
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