mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo

Antibody-based drugs are a leading class of biologics used to treat a variety of diseases, including cancer. However, wide antibody implementation is hindered by manufacturing challenges and high production cost. Use of in-vitro-transcribed mRNA (IVT-mRNA) for endogenous protein expression has the p...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Rybakova, Yulia, Kowalski, Piotr S., Huang, Yuxuan, Gonzalez, John T., Heartlein, Michael W., DeRosa, Frank, Delcassian, Derfogail, Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698250/
https://ncbi.nlm.nih.gov/pubmed/31160223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.05.012
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