Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketide intermediates through a dehydration reaction. Sev...

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Dades bibliogràfiques
Publicat a:J Ind Microbiol Biotechnol
Autors principals: Barajas, Jesus F., McAndrew, Ryan P., Thompson, Mitchell G., Backman, Tyler W. H., Pang, Bo, de Rond, Tristan, Pereira, Jose H., Benites, Veronica T., Martín, Héctor García, Baidoo, Edward E. K., Hillson, Nathan J., Adams, Paul D., Keasling, Jay D.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
Matèries:
Natural Products - Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697708/
https://ncbi.nlm.nih.gov/pubmed/31115703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10295-019-02189-z
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