Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketide intermediates through a dehydration reaction. Sev...

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Detalhes bibliográficos
Publicado no:J Ind Microbiol Biotechnol
Main Authors: Barajas, Jesus F., McAndrew, Ryan P., Thompson, Mitchell G., Backman, Tyler W. H., Pang, Bo, de Rond, Tristan, Pereira, Jose H., Benites, Veronica T., Martín, Héctor García, Baidoo, Edward E. K., Hillson, Nathan J., Adams, Paul D., Keasling, Jay D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Natural Products - Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697708/
https://ncbi.nlm.nih.gov/pubmed/31115703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10295-019-02189-z
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