Consecutive day HSP90 inhibitor administration improves efficacy in murine models of KIT-driven malignancies and canine mast cell tumors

PURPOSE: STA-1474, prodrug of the heat shock protein 90 inhibitor (HSP90i) ganetespib, previously demonstrated activity in canine preclinical models of cancer; interestingly, prolonged infusions were associated with improved biologic activity. The purpose of this study was to identify the ideal trea...

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Vydáno v:Clin Cancer Res
Hlavní autoři: London, Cheryl A., Acquaviva, Jaime, Smith, Donald L., Sequeira, Manuel, Ogawa, Luisa Shin, Gardner, Heather L., Bernabe, Louis Feo, Bear, Misty D., Bechtel, Sandra A., Proia, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696991/
https://ncbi.nlm.nih.gov/pubmed/30171047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0703
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