KTN0158, a humanized anti-KIT monoclonal antibody, demonstrates biologic activity against both normal and malignant canine mast cells

PURPOSE: KTN0158 is a novel anti-KIT antibody that potently inhibits wild-type and mutant KIT. This study evaluated the safety, biologic activity and pharmacokinetic/pharmacodynamics profile of KTN0158 in dogs with spontaneous mast cell tumors (MCT) as a prelude to human clinical applications. EXPER...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: London, Cheryl A., Gardner, Heather L., Rippy, Sarah, Post, Gerald, La Perle, Krista, Crew, Linda, Lopresti-Morrow, Lori, Garton, Andrew J., McMahon, Gerald, LaVallee, Theresa, Gedrich, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418113/
https://ncbi.nlm.nih.gov/pubmed/27815356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2152
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