LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling

During sepsis, the increased synthesis of circulating lipopolysaccharide (LPS)-binding protein (LBP) activates LPS/TLR4 signaling in renal resident cells, leading to acute kidney injury (AKI). Pericytes are the major source of myofibroblasts during chronic kidney disease (CKD), but their involvement...

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Publicat a:Int J Mol Sci
Autors principals: Castellano, Giuseppe, Stasi, Alessandra, Franzin, Rossana, Sallustio, Fabio, Divella, Chiara, Spinelli, Alessandra, Netti, Giuseppe Stefano, Fiaccadori, Enrico, Cantaluppi, Vincenzo, Crovace, Antonio, Staffieri, Francesco, Lacitignola, Luca, Grandaliano, Giuseppe, Simone, Simona, Pertosa, Giovanni Battista, Gesualdo, Loreto
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696277/
https://ncbi.nlm.nih.gov/pubmed/31357597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153682
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