Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials

The biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease, requiring renal replacement therapy. Since the discovery of pivotal mechanisms of senescence such as cell cycle arrest, apoptosis inhibition...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Franzin, Rossana, Stasi, Alessandra, Ranieri, Elena, Netti, Giuseppe Stefano, Cantaluppi, Vincenzo, Gesualdo, Loreto, Stallone, Giovanni, Castellano, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117359/
https://ncbi.nlm.nih.gov/pubmed/33995028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.630419
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