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Reduced model to predict thrombin and fibrin during thrombosis on collagen/tissue factor under venous flow: Roles of γ’-fibrin and factor XIa
During thrombosis, thrombin generates fibrin, however fibrin reversibly binds thrombin with low affinity E-domain sites (K(D) = 2.8 μM) and high affinity γ’-fibrin sites (K(D) = 0.1 μM). For blood clotting on collagen/tissue factor (1 TF-molecule/μm(2)) at 200 s(-1) wall shear rate, high μM-levels o...
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| Foilsithe in: | PLoS Comput Biol |
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| Main Authors: | , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science
2019
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6695209/ https://ncbi.nlm.nih.gov/pubmed/31381558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007266 |
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