A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease remain poorly understood. In humans, elevated UA leve...

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Vydáno v:PLoS Genet
Hlavní autoři: Lang, Sven, Hilsabeck, Tyler A., Wilson, Kenneth A., Sharma, Amit, Bose, Neelanjan, Brackman, Deanna J., Beck, Jennifer N., Chen, Ling, Watson, Mark A., Killilea, David W., Ho, Sunita, Kahn, Arnold, Giacomini, Kathleen, Stoller, Marshall L., Chi, Thomas, Kapahi, Pankaj
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695094/
https://ncbi.nlm.nih.gov/pubmed/31415568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008318
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