A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease remain poorly understood. In humans, elevated UA leve...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Lang, Sven, Hilsabeck, Tyler A., Wilson, Kenneth A., Sharma, Amit, Bose, Neelanjan, Brackman, Deanna J., Beck, Jennifer N., Chen, Ling, Watson, Mark A., Killilea, David W., Ho, Sunita, Kahn, Arnold, Giacomini, Kathleen, Stoller, Marshall L., Chi, Thomas, Kapahi, Pankaj
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695094/
https://ncbi.nlm.nih.gov/pubmed/31415568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008318
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