Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal inte...

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Dades bibliogràfiques
Publicat a:PLoS Genet
Autors principals: Akagi, Kazutaka, Wilson, Kenneth A., Katewa, Subhash D., Ortega, Mauricio, Simons, Jesse, Hilsabeck, Tyler A., Kapuria, Subir, Sharma, Amit, Jasper, Heinrich, Kapahi, Pankaj
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233930/
https://ncbi.nlm.nih.gov/pubmed/30383748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007777
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