Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal inte...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Akagi, Kazutaka, Wilson, Kenneth A., Katewa, Subhash D., Ortega, Mauricio, Simons, Jesse, Hilsabeck, Tyler A., Kapuria, Subir, Sharma, Amit, Jasper, Heinrich, Kapahi, Pankaj
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233930/
https://ncbi.nlm.nih.gov/pubmed/30383748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007777
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