Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal inte...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Akagi, Kazutaka, Wilson, Kenneth A., Katewa, Subhash D., Ortega, Mauricio, Simons, Jesse, Hilsabeck, Tyler A., Kapuria, Subir, Sharma, Amit, Jasper, Heinrich, Kapahi, Pankaj
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233930/
https://ncbi.nlm.nih.gov/pubmed/30383748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007777
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