Intestinal IRE1 is required for increased triglyceride metabolism and longer lifespan under Dietary Restriction

Dietary restriction (DR) is one of the most robust lifespan-extending interventions in animals. The beneficial effects of DR involve a metabolic adaptation towards increased triglyceride usage. The regulatory mechanism and the tissue specificity of this metabolic switch remain unclear. Here we show...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Luis, Nuno Miguel, Wang, Lifen, Ortega, Mauricio, Deng, Hansong, Katewa, Subhash D., Li, Patrick Wai-Lun, Karpac, Jason, Jasper, Heinrich, Kapahi, Pankaj
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089850/
https://ncbi.nlm.nih.gov/pubmed/27783936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.003
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