Peripheral circadian clocks mediate dietary restriction dependent changes in lifespan and fat metabolism in Drosophila

Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that the core circadian clock genes, timeless (tim) and period (per), are required...

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Vydáno v:Cell Metab
Hlavní autoři: Katewa, Subhash D., Akagi, Kazutaka, Bose, Neelanjan, Rakshit, Kuntol, Camarella, Timothy, Zheng, Xiangzhong, Hall, David, Davis, Sonnet, Nelson, Christopher S., Brem, Rachel B., Ramanathan, Arvind, Sehgal, Amita, Giebultowicz, Jadwiga M., Kapahi, Pankaj
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715572/
https://ncbi.nlm.nih.gov/pubmed/26626459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.10.014
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