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Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological dise...

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Autors principals: Krishnan, Natraj, Rakshit, Kuntol, Chow, Eileen S., Wentzell, Jill S., Kretzschmar, Doris, Giebultowicz, Jadwiga M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291167/
https://ncbi.nlm.nih.gov/pubmed/22227001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.12.034
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