AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis

Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycos...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Chen, Ruochan, Zhu, Shan, Zeng, Ling, Wang, Qingde, Sheng, Yi, Zhou, Borong, Tang, Daolin, Kang, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694796/
https://ncbi.nlm.nih.gov/pubmed/31440260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01904
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