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Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors

Rocaglates are a family of natural products isolated from the genus Aglaia which possess a highly substituted cyclopenta[b]benzofuran skeleton and inhibit cap-dependent protein synthesis. Rocaglates are attractive compounds due to their potential for inhibiting tumor cell maintenance in vivo by spec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Zhang, Wenhan, Chu, Jennifer, Cyr, Andrew M., Yueh, Han, Brown, Lauren E., Wang, Tony T., Pelletier, Jerry, Porco, John A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693944/
https://ncbi.nlm.nih.gov/pubmed/31310112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06446
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