Amidino-Rocaglates – A potent class of eIF4A inhibitors

Rocaglates share a common cyclopentabenzo[b]furan core that inhibit eukaryotic translation initiation by modifying the behaviour of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the association between eIF4A and RNA which can lead to the formation of steric barrier...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, Devine, William G., Beglov, Dmitri, Henkel, Thomas, Brown, Lauren E., Vadja, Sandor, Porco, John A., Pelletier, Jerry
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874763/
https://ncbi.nlm.nih.gov/pubmed/31519508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.08.008
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