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Amidino-Rocaglates – A potent class of eIF4A inhibitors
Rocaglates share a common cyclopentabenzo[b]furan core that inhibit eukaryotic translation initiation by modifying the behaviour of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the association between eIF4A and RNA which can lead to the formation of steric barrier...
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| Published in: | Cell Chem Biol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6874763/ https://ncbi.nlm.nih.gov/pubmed/31519508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.08.008 |
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