טוען...
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting RAS-decoupled proliferative RAF-MEK-ERK signaling. We have engineered luciferase-based biosensors to systematically track full-length BRAF conformations and interactions affected by tu...
שמור ב:
| הוצא לאור ב: | Sci Adv |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Association for the Advancement of Science
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693913/ https://ncbi.nlm.nih.gov/pubmed/31453322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav8463 |
| תגים: |
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