BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS

Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting RAS-decoupled proliferative RAF-MEK-ERK signaling. We have engineered luciferase-based biosensors to systematically track full-length BRAF conformations and interactions affected by tu...

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Dettagli Bibliografici
Pubblicato in:Sci Adv
Autori principali: Röck, Ruth, Mayrhofer, Johanna E., Torres-Quesada, Omar, Enzler, Florian, Raffeiner, Andrea, Raffeiner, Philipp, Feichtner, Andreas, Huber, Roland G., Koide, Shohei, Taylor, Susan S., Troppmair, Jakob, Stefan, Eduard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693913/
https://ncbi.nlm.nih.gov/pubmed/31453322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav8463
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