Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies

Kinase-targeted therapies have the potential to improve the survival of patients with cancer. However, the cancer-specific spectrum of kinase alterations exhibits distinct functional properties and requires mutation-oriented drug treatments. Besides post-translational modifications and diverse inter...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Mayrhofer, Johanna E., Enzler, Florian, Feichtner, Andreas, Röck, Ruth, Fleischmann, Jakob, Raffeiner, Andrea, Tschaikner, Philipp, Ogris, Egon, Huber, Roland G., Hartl, Markus, Schneider, Rainer, Troppmair, Jakob, Torres-Quesada, Omar, Stefan, Eduard
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2020
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733820/
https://ncbi.nlm.nih.gov/pubmed/33229534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012150117
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