Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies

Kinase-targeted therapies have the potential to improve the survival of patients with cancer. However, the cancer-specific spectrum of kinase alterations exhibits distinct functional properties and requires mutation-oriented drug treatments. Besides post-translational modifications and diverse inter...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mayrhofer, Johanna E., Enzler, Florian, Feichtner, Andreas, Röck, Ruth, Fleischmann, Jakob, Raffeiner, Andrea, Tschaikner, Philipp, Ogris, Egon, Huber, Roland G., Hartl, Markus, Schneider, Rainer, Troppmair, Jakob, Torres-Quesada, Omar, Stefan, Eduard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733820/
https://ncbi.nlm.nih.gov/pubmed/33229534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012150117
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados