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Impact of kinase activating and inactivating patient mutations on binary PKA interactions
The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon receptor initiated cAMP-mobilization, PKA regulatory subunits (R) bind cAMP thereby triggering dissociation and activation...
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| Publicado no: | Front Pharmacol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539479/ https://ncbi.nlm.nih.gov/pubmed/26347651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00170 |
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