Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation

Fibrotic scarring drives the progression of heart failure after myocardial infarction (MI). Therefore, the development of specific treatment regimens to counteract fibrosis is of high clinical relevance. The transcription factor sex-determining region Y box 9 (SOX9) functions as an important regulat...

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Foilsithe in:JCI Insight
Main Authors: Scharf, Gesine M., Kilian, Katja, Cordero, Julio, Wang, Yong, Grund, Andrea, Hofmann, Melanie, Froese, Natali, Wang, Xue, Kispert, Andreas, Kist, Ralf, Conway, Simon J., Geffers, Robert, Wollert, Kai C., Dobreva, Gergana, Bauersachs, Johann, Heineke, Joerg
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693887/
https://ncbi.nlm.nih.gov/pubmed/31310588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126721
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