Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation

Fibrotic scarring drives the progression of heart failure after myocardial infarction (MI). Therefore, the development of specific treatment regimens to counteract fibrosis is of high clinical relevance. The transcription factor sex-determining region Y box 9 (SOX9) functions as an important regulat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Scharf, Gesine M., Kilian, Katja, Cordero, Julio, Wang, Yong, Grund, Andrea, Hofmann, Melanie, Froese, Natali, Wang, Xue, Kispert, Andreas, Kist, Ralf, Conway, Simon J., Geffers, Robert, Wollert, Kai C., Dobreva, Gergana, Bauersachs, Johann, Heineke, Joerg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693887/
https://ncbi.nlm.nih.gov/pubmed/31310588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126721
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