Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart

Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular chaperones are required for procollagen biosynthesis, including heat shock protein 47 (Hsp47). To determine the cell type...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Khalil, Hadi, Kanisicak, Onur, Vagnozzi, Ronald J., Johansen, Anne Katrine, Maliken, Bryan D., Prasad, Vikram, Boyer, Justin G., Brody, Matthew J., Schips, Tobias, Kilian, Katja K., Correll, Robert N., Kawasaki, Kunito, Nagata, Kazuhiro, Molkentin, Jeffery D.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693833/
https://ncbi.nlm.nih.gov/pubmed/31393098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128722
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