Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that co...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Khalil, Hadi, Kanisicak, Onur, Prasad, Vikram, Correll, Robert N., Fu, Xing, Schips, Tobias, Vagnozzi, Ronald J., Liu, Ruijie, Huynh, Thanh, Lee, Se-Jin, Karch, Jason, Molkentin, Jeffery D.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617658/
https://ncbi.nlm.nih.gov/pubmed/28891814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94753
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