Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-induced F-actin Assemblies

Debilitating heart conditions, notably dilated and hypertrophic cardiomyopathies (CM), are associated with point mutations in metavinculin, a larger isoform of the essential cytoskeletal protein vinculin. Metavinculin is co-expressed with vinculin at sub-stoichiometric ratios in cardiac tissues. Car...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Sarker, Muzaddid, Lee, Hyunna T., Mei, Lin, Krokhotin, Andrey, de los Reyes, Santiago Espinosa, Yen, Laura, Costantini, Lindsey M., Griffith, Jack, Dokholyan, Nikolay V., Alushin, Gregory M., Campbell, Sharon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693633/
https://ncbi.nlm.nih.gov/pubmed/30844403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.02.024
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